Aldosterone up‐regulates K Ca 1.1 (BK) channel‐mediated colonic K + secretion
نویسندگان
چکیده
منابع مشابه
Distal colonic K(+) secretion occurs via BK channels.
K(+) secretion in the kidney and distal colon is a main determinant of K(+) homeostasis. This study investigated the identity of the relevant luminal secretory K(+) ion channel in distal colon. An Ussing chamber was used to measure ion transport in the recently generated BK channel-deficient (BK(-/-)) mice. BK(-/-) mice display a significant colonic epithelial phenotype with (1) lack of Ba(2+)-...
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Distal colonic K(+) excretion is determined by the balance of K(+) absorption and K(+) secretion of the enterocytes. K(+) secretion occurs via active basolateral K(+) uptake mostly via the NKCC1 co-transporter followed by K(+) exit via a luminal K(+) channel. The specific focus here is directed towards the luminal secretory K(+) channel (1). Several recent observations highlight the pivotal rol...
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A low Na, high K diet (LNaHK) is associated with a low rate of cardiovascular (CV) disease in many societies. Part of the benefit of LNaHK relies on its diuretic effects; however, the role of aldosterone (aldo) in the diuresis is not understood. LNaHK mice exhibit an increase in renal K secretion that is dependent on the large, Ca-activated K channel, (BK-α with accessory BK-β4; BK-α/β4). We hy...
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Secretion of Cl(-) and K(+) in the colonic epithelium operates through a cellular mechanism requiring K(+) channels in the basolateral and apical membranes. Transepithelial current [short-circuit current (I(sc))] and conductance (G(t)) were measured for isolated distal colonic mucosa during secretory activation by epinephrine (Epi) or PGE(2) and synergistically by PGE(2) and carbachol (PGE(2) +...
متن کاملA SIMPLE DERIVATION OF ζ ( 1 − k ) = − Bk / k
We will show that ζK(s, x) extends for all s ∈ C and is analytic everywhere except at s = 1 where it has a simple pole. It turns out that the special values ζK(1 − k, x) can be written as a polynomial in x, thus giving a generalization of the Bernoulli polynomials (in the case K is totally real). This work had its genesis in looking for simple proofs of the well-known formula ζ(1−k) = −Bk/k, wh...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2007
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.21.6.a956-b